11-inspired Springsteen song "You're Missing" provided one of the more heart-wrenching moments on "The Rising" in 2002.
In a band with larger-than-life characters such as saxophonist Clarence Clemons and bandana-wrapped guitarist "Little" Steven Van Zandt, Federici was content to play in his familiar position to the side of the stage. But his playing was as vital to Springsteen's live show as any instrument in the band.
Federici released a pair of solo albums that veered from the E Street sound and into soft jazz. Bandmates Nils Lofgren on guitar and Garry Tallent on bass joined Federici on his 1997 debut, "Flemington." In 2005, Federici released its follow-up, "Out of a Dream."
Federici had taken a leave of absence during the band's tour in November 2007 to pursue treatment for melanoma, and was temporarily replaced by veteran musician Charles Giordano.
At the time, Springsteen described Federici as "one of the pillars of our sound and has played beside me as a great friend for more than 40 years. We all eagerly await his healthy and speedy return."
Besides his work with Springsteen, Federici played on albums by an impressive roster of other artists: Van Zandt, Joan Armatrading, Graham Parker, Gary U.S. Bonds and Garland Jeffreys.